Faculty & Scientific Staff
Alice Wiedeman, PhD
Dr. Alice Wiedeman received her BS degree in Molecular Biology and Chemistry from Harvey Mudd College in Claremont, CA. Alice then joined Seattle Children’s Research Institute where she studied mechanisms of disease pathogenesis in pediatric lupus, before going on to earn her PhD in Immunology and Certificate in Molecular Medicine from University of Washington in Seattle, WA. There, Alice researched the development of autoreactive B cells and the regulation of plasmacytoid dendritic cells in health and disease. She next joined a Seattle area preclinical contract research organization, SNBL USA, Ltd. (now Altasciences), where she performed immune monitoring under a regulated environment.
In 2015, Alice joined Benaroya Research Institute (BRI) as a staff scientist in the laboratory of Dr. Alice Long where she applied her experience with immune dysregulation in human autoimmunity to research the role of self-reactive T cells in driving and preventing progression of type 1 diabetes. In 2021, Alice was promoted to manager of the Human Immunophenotyping Core at BRI, where she continues to leverage her knowledge of the immune system and high-dimensional single-cell technologies to aid researchers in advancing human health.
Alice is a Puget Sound area native. She spends her time outside the lab having fun with her two young daughters, exploring the outdoors, and playing board games.
Featured Publications
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Nov 2022
Inflammatory bone marrow signaling in pediatric acute myeloid leukemia distinguishes patients with poor outcomes.
Nat CommunBolouri H, Ries RE, Wiedeman AE, Hylkema T, Scheiding S, Gersuk VH, O'Brien K, Nguyen QA, Smith JL, Long SA, Meshinchi S -
May 2022
Chemokines, Soluble PD-L1, and Immune Cell Hyporesponsiveness are Distinct Features of SARS-CoV-2 Critical Illness.
Am J Physiol Lung Cell Mol PhysiolMorrell ED, Bhatraju PK, Sathe NA, Lawson J, Mabrey L, Holton SE, Presnell SR, Wiedeman A, Acosta-Vega C, Mitchem MA, Liu T, Chai XY, Sahi S, Brager C, Orlov M, Sakr SS, Sader A, Lum DM, Koetje N, Garay A, Barnes E, Cromer G, Bray MK, Pipavath S, Fink SL, Evans L, Long SA, West TE, Wurfel MM, Mikacenic C -
Jan 2022
Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.
Eur J ImmunolYang JHM, Ward-Hartstonge KA, Perry DJ, Blanchfield JL, Posgai AL, Wiedeman AE, Diggins K, Rahman A, Tree TIM, Brusko TM, Levings MK, James EA, Kent SC, Speake C, Homann D, Long SA, Immunology of Diabetes Society T-Cell Cytometry Group. -
Jan 2022
Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity.
Sci Transl MedLambert K, Moo KG, Arnett A, Goel G, Hu A, Flynn KJ, Speake C, Wiedeman AE, Gersuk VH, Linsley PS, Greenbaum CJ, Long SA, Partridge R, Buckner JH, Khor B -
Apr 2022
A simple strategy for sample annotation error detection in cytometry datasets.
Cytometry ASmithmyer ME, Wiedeman AE, Skibinski DAG, Savage AK, Acosta-Vega C, Scheiding S, Gersuk VH, O'Rourke C, Long SA, Buckner JH, Speake C
BRI External Core Labs
BRI’s core laboratories are home to some of the most advanced scientific technologies available. These tools fuel breakthroughs in the lab and lead to advances in patient care. All BRI scientists, as well as scientists from outside of BRI, can access our core labs. Each lab is led by a field-expert who is available to support scientists as they leverage these tools and technologies.
